I listen to Remember When.
It's by the same guys that do unclegamer radio. All they talk about is cool shit like Back to the Future, Transformers, Futurama, Lost, Voltron, Star Wars, Star Trek, Superman (the old movies), Iron Man, Family Guy, American Dad, Batman Begins, The Dark Knight, and shit knows what else. They will go off on crazy tangents, but it never seems to be out of control or too random. I highly recommend the podcast.
I have a lot of podcasts that I subscribe to, but this is the one that I make sure I always listen to when a new episode becomes available.http://talkingaboutgames.com/content/blogcategory/48/73/
Other then that...
Video: Ask A Ninja, Code Monkeys, Break.com, Ninja Warrior, Unbeatable Banzuke, Happy Tree Friends, Strong Bad Email, Track Shun Anime Review.
Audio: 1up, 2600 The Hacker Quarterly, tons of ESPN shit that I never really get to, Free Talk Live (Libertarian/Free Market Talk Radio), Red Bar Radio, and some other random shit.
I'm also kind of a podcast junkie. Though I don't twitch if I miss an episode here and there, so it's all right.